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We are powder
technology consultants with extensive expertise and experience in all
facets of powder technology and its application to pharmaceutical drug
delivery, medical device, food stuff, plastic, glass and metal products
since 1980. Example projects include a meter dose drug
inhaler/nebulizer; tablets, micro-capsules, micro-particles and pellets
that either dissolve or release a drug at a controlled rate; wound
treatment and healing powders; a mixture of hydroxyapatite particles and
tricalcium phosphate powder for bone implantation; sodium and potassium
EDTA anticoagulants; lithium heparin anticoagulant; fumed silica as a
gelling mixture agent; rabbit brain powder; liquid absorbing powder for
diapers, feminine napkins and hospital waste fluids; quartz silica for
blood coagulation; oxidized cellulose powder for wound healing and
hemostasis; and various rubber formulation powders. Your company
can realize significant profitability, performance and quality benefits
through powder handling and processing improvements.
Powder
materials exhibit a number of technological challenges with their
manufacture, storage, transportation, mixing, dusting, characterization,
packing, crushing and milling.
Symptoms of a
non-optimized product system utilizing a powder include: unacceptable
rehydration, dissolution and solubility rate/reproducibility of the
powder mixture; degradation, loss of drug activity, reduction of product
self-life; drug mixture heterogeneity both before and during use; clogging
of spray nozzle; and loss of delivered drug.
Utilization of the
appropriate binders and adhesives; disintegrating agents; fillers;
lubricants; wetting agents/surfactants; glidants; flavoring and
sweetening agents, all of these can have a significant impact on the
performance of a product using a powder.
Typical powder
dispersion problems include: chemical and morphological heterogenity of
the surface, dissolution or isomorphous substitution of constituent
components (metals), dependency of the surface and solution (dissolved or
added) ion species. A number of interrelated physico-chemical
properties, such as pH (acidity), pI (ionic strength), pe (redox) and pc
(concentration) influence the properties of the dispersion beside of the
pressure and temperature.
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TechnoBusiness
Solutions
403 Christie Ct.,
Stewartsville, NJ 08886 USA
Costas B. Chantzis,
CEO
Tel.:
908.387.9276
Fax: 908.387.0447
Email
Home
Home
Who We Are
Unique Strengths
Our Services
Projects Resume
Your Next
Step
Write Us
What's New
Articles
Ask
SolvWizSM For FREE
TechnoBusiness
Solutions
403 Christie Ct.,
Stewartsville, NJ 08886 USA
Costas B. Chantzis,
CEO
Tel.:
908.387.9276
Fax: 908.387.0447
Email
Home
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